Melanoma-associatedantigen1,MAGE-1antigen,AntigenMZ2-E,Cancer/testisantigen1.1,CT1.1,MAGEA1,MAGE1,MAGE1A,MGC9326.
MelanomaantigenfamilyA1belongstotheMAGEAgenefamily,whosemembersencodeproteinswith50to80%sequenceidentitytoeachother.TheMAGEAgeneswhichareclusteredatchromosomallocationXq28,havebeenimplicatedinsomehereditarydisorders,suchasdyskeratosiscongenita.
Humanmalignantneoplasmscarryrejectionantigensthatarerecognizedbythepatientsautologous,tumordirectedandspecific,cytolytic,CD8+Tlymphocyteclones(CTL).AnimportantgroupofantigensiscodedbytheMAGEfamilyofgenes.Itwasidentifiedthatmelanomasandprimaryglialbraintumorsexpresscommonmelanomaassociatedantigens(MAAs).
BecauseMAGE-1isexpressedonasignificantproportionofhumanneoplasmsofvarioushistologicaltypes(melanoma,braintumorsofglialorigin,neuroblastoma,non-smallcelllungcancer,breast,gastric,colorectal,ovarian,renalcellcarcinomas)andnotonnormaltissues,theencodedantigenmayserveasa
Markerofearlydetectionandtargetforcancerimmunotherapy.
MAGEA1HumanRecombinantfulllengthproteinexpressedinE.coli,MAGEA1isantibodyreactive.TheMAGEA1isfusedtoaGSTtagpurifiedbyproprietarychromatographictechniques.
EscherichiaColi.
SterileFilteredclearsolution.
MAGEA1in50mMTris-Acetate,pH7.5,1mMEDTAand20%Glycerol.
Storevialat-20°Cto-80°C.Whenstoredattherecommendedtemperature,thisproteinisstablefor12months.
Pleasepreventfreeze-thawcycles.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.