Borreliabelongstoagenusofbacteriaofthespi
Rochetephylum.Borreliacausesborreliosis,whichisazoonotic,vector-bornediseasetransmittedmainlybyticksandsomebylice,dependingonthespecies.Ofthe36knownspeciesofBorrelia,12aredistinguishedtocauseLymediseaseorborreliosisandaretransmittedbyticks.ThemainBorreliaspeciescausingLymediseaseareBorreliaburgdorferi,Borreliaafzelii,andBorreliagarinii.TheBorreliagenusmembershavealinearchromosomewhichisabout900kbpinlengthaswellasanexcessofbothlinearandcircularplasmidsinthe5-220kbpsizerange.Theplasmidsareatypical,ascomparedtomostbacterialplasmids,sincetheycontainmanyparalogoussequences,alargenumberofpseudogenesand,insomecases,essentialgenes.Moreover,anumberoftheplasmidshavefeaturessuggestingthattheyareprophages.
RecombinantBorreliaAfzeliiOuterSurfaceProteinCproducedinE.coliisanon-glycosylated,polypeptidechainhavingacalculatedmolecularmassof22,151Dalton.BorreliaAfzeliiOspCisexpressedwitha10xHistagatN-terminusandpurifiedbyproprietarychromatographictechniques.
EscherichiaColi.
SterileFilteredclearsolution.
BorreliaAfzeliiOspCissuppliedin20mMHEPESbufferpH-7.6,250mMNaCland20%glycerol.
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Avoidmultiplefreeze-thawcycles.
Greaterthan80.0%asdeterminedbySDS-PAGE.
1.BindsIgG-andIgM-typehumanantibodies.2.ImmunodottestwithLymediseasepositive/negativeplasma.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.