Cataloguenumber
HOR-280
Synonyms
Vasopressin-neurophysin2-copeptin,AVP-NPII,VP,ADH,ARVP,AVRP,Argipressin,Argininevasopressin,AVP,Vasopressin,AntidiureticHormone.
Introduction
Argininevasopressin(AVP),alsoknownasargipressinorantidiuretichormone(ADH),isahumanhormonethatisreleasedwhenthebodyislowonwater;itcausesthekidneystoconservewater,butnotsalt,byconcentratingtheurineandreducingurinevolume.Italsoraisesbloodpressurebyinducingmoderatevasoconstriction.Ithasvariouseffectsinthebrain.Averysimilarsubstance,lysinevasopressin(LVP)orlypressin,hasthesamefunctioninpigsandisoftenusedinhumantherapy.Vasopressinisapeptidehormone.Itisderivedfromapreprohormoneprecursorthatissynthesizedinthehypothalamus,fromwhichitisliberatedduringtransporttotheposteriorpituitary.Mostofitisstoredintheposteriorpartofthepituitaryglandtobereleasedintothebloodstream;someofitisalsoreleaseddirectlyintothebrain.AVPallowswaterreabsorptionbytheintroductionofadditionalwaterchannelsincorticalandinnermedullarycollectingducts.
Description
Prospec’s8-L-ArginineVasopressin’smolecularweightis1084.24Daltonandthemolecularformulais:C
46H
65N
15O
12S
2.
PhysicalAppearance
SterileFilteredWhitelyophilized(freeze-dried)powder.
Formulation
Theprotein(1mg/ml)waslyophilizedwithnoadditives.
Solubility
ItisrecommendedtoreconstitutethelyophilizedVasopressininsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
LyophilizedVasopressinalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionVasopressinshouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.
Purity
Greaterthan98.0%asdeterminedbybyRP-HPLC.
Aminoacidsequence
C[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Arg-Gly-NH2.
SafetyDataSheet
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.