Goserelinisahormonesimilartotheonenormallyreleasedfromthehypothalamusglandinthebrain(GnRHsuper-ago
NIST).Itisusedtotreatforprostateandbreastcancer.Goserelindecreasestheamountofestrogenandtestosteronebythistreatingendometriosisandcancerofthebreast,andcanhelpthintheuterusliningbeforesurgery.Goserelinpreventsthegrowthoftissueassociatedwithendometriosis.Reducingtheamountoftestosteroneisonewayoftreatingprostatecancer.
Goserelincontains10aminoacidsGlu1-His2-Trp3-Ser4-Tyr5-D-Ser(tBu)6-Leu7-Arg8-Pro9-AzGly10-NH2andhavingamolecularweightof1269.43Dalton.
SterileFilteredWhitelyophilized(freeze-dried)powder.
TheGoserelinpeptidewaslyophilizedwithnoadditives.
ItisrecommendedtoreconstitutethelyophilizedGoserelininsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
LyophilizedGoserelinalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionGoserelinshouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.
Greaterthan98.0%asdeterminedby:(a)AnalysisbyRP-HPLC.(b)AnalysisbySDS-PAGE.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.