Deslorelinisbeingstudiedinthetreatmentofcancerasawaytoblocksexhormonesmadebytheovariesortesticles.Itbelongstothefamilyofdrugscalledgonadotropin-releasinghormoneanalogs.Itisusedfortheinductionofovulationinmares.Deslorelinbindstoandactivatespituitarygonadotropinreleasinghormone(GnRH)receptors.Continuous,prolongedadmi
NISTrationofgoserelininmalesresultsinpituitaryGnRHreceptordesensitizationandinhibitionofpituitarysecretionoffolliclestimulatinghormone(FSH)andluteinizinghormone(LH),le
ADIngtoasignificantdeclineintestosteroneproduction;infemales,prolongedadministrationresultsinadecreaseinestradiolproduction.
DeslorelinisapotentLHRH/GnRHagonisthasamolecularformulaofC64H83N17O12,pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHC2H5havinganMwof1281.64Dalton.
SterileFilteredWhitelyophilized(freeze-dried)powder.
TheDeslorelinpeptidewaslyophilizedwithnoadditives.
ItisrecommendedtoreconstitutethelyophilizedDeslorelininsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
LyophilizedDeslorelinalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionDeslorelinshouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.
Greaterthan99.0%asdeterminedbyRP-HPLC.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.