Prospec/IL37 Human/Interleukin-37 Human Recombinant/3x2µg/CYT-011-3x2µg,Prospec,,Prospec,prospecbio,ProSpec-Tany,Prospec中国试剂购买网站正品prospecbio生物试剂1,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Prospec/IL37 Human/Interleukin-37 Human Recombinant/3x2µg/CYT-011-3x2µg

产品编号：CYT-011-3x2µg

市场价：¥1000.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$50.00

品牌： Prospec

公司：Prospec-Tany

公司分类：

商品介绍

Cataloguenumber

CYT-011

Synonyms

Interleukin-37,FIL1zeta,IL-1X,Interleukin-1familymember7,IL-1F7,Interleukin-1homolog4,IL-1H,IL-1H4,Interleukin-1zeta,IL-1zeta,Interleukin-1-relatedprotein,IL-1RP1,Interleukin-23,IL-37,IL37,FIL1Z,IL1F7,IL1H4,IL1RP1,FIL1,FIL1(ZETA).

Introduction

Humaninterleukinfamily1,member7(IL1F7)belongstotheinterleukin1cytokinefamily.Thereare5alternativelysplicedtranscriptvariantsencodingdistinctisoformswithdistinctexpressionprofiles.ThelongestIL-1F7transcript,namedIL1F7borIL1F7isoform1,encodesa218aaresiduesproproteinandcontaininga45aapropeptidewhichiscleavedtoproduceamatureprotein.IL1F7bbindstoIL18Rbwithlowaffinityhoweveritdoesn’texertanyIL18agoNISTicorantagonisticeffects.IL1F7balsobindsIL18BP(interleukin18bindingprotein),whichisaninhibitorybindingproteinofinterleukin18(IL18),andafterwardformsacomplexwithIL18receptorbetasubunit,andthroughwhichitinhibitstheactivityofIL18.

Description

Interleukin-37HumanRecombinantproducedinE.Coliisasingle,non-glycosylated,Polypeptidechaincontaining167aminoacids(Lys27-Asp192)andhavingamolecularmassof18.6kDa.TheIL37ispurifiedbyproprietarychromatographictechniques.

Source

EscherichiaColi.

PhysicalAppearance

SterileFilteredWhitelyophilized(freeze-dried)powder.

Formulation

IL37waslyophilizedfroma0.2μMfilteredsolutionof20mMPB,150mMNaCland2mMDTTpH7.4.

Solubility

ItisrecommendedtoquickspinfollowedbyreconstitutionofIL37inPBStoaconcentrationnolessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.

StABIlity

LyophilizedIL37althoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionIL-37shouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Pleasepreventfreeze-thawcycles.

Purity

Greaterthan95.0%asdeterminedby:(a)AnalysisbyRP-HPLC.(b)AnalysisbySDS-PAGE.

Aminoacidsequence

MKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEK

GSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYR

AQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAE

MSPSEVSD.

BIOLOGicalActivity

AsmeasuredbyitsbindingabilityinafunctionalELISA,immobilizedIL1F7at1µg/ml(100µl/well)canbindrhIL-18R/FcChimerawithalinearrangeof0.015-1µg/ml.

SafetyDataSheet

SDS

Usage

Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.

品牌介绍

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。