Ganciclovir(GCV)isapro-drugnucleosideanalogthatisactivatedbyphosphorylation.Itisusefulinthestudyofgenetherapyincancerresearch.Ganciclovirisasyntheticanalogueof2"-deoxy-guanosine.Itisinitiallyphosphorylatedtoadeoxyguanosinetriphosphate(dGTP)analogue.ThismechanismcompetitivelyinhibitstheintegrationofdGTPbyviralDNApolymerase,resultingintheterminationofelongationofviralDNA.Uponexpressionofaviralsuicidegeneencodingthymidinekinase,thenon-toxicpro-drugisconvertedtoaphosphorylatedactiveanalogandisincorporatedintotheDNAofreplicatingeukaryoticcells,causingdeathofthemalignantdividingcell.Thecellcycleisirrevers
IBLyarrestedattheG2-Mcheckpoint.Gapjunctioninvolvementintheganciclovirbystandereffecthasbeenstudied.Ganciclovirhasbeenusedtostudylossoftelomeresandtoevaluatesensitivityofvirusestoantiviraltreatments.Ganciclovirisusedinmolecular
BIOLOGyforselectionagainstrandomrecombinationeventswhenhomologousrecombinationofageneofinterestisrequired.
SterileFilteredWhitelyophilized(freeze-dried)powder.
ItisrecommendedtoreconstitutethelyophilizedGanciclovirinsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
LyophilizedGancicloviralthoughstableatroomtemperaturefor3weeks,shouldbestoredat4°C.
Greaterthan99.0%.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.