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℡ 4000-520-616
℡ 4000-520-616
Prospec/NRG1 A Human/Neuregulin-1/Heregulin Alpha (EGF Domain) Human Recombinant/20µg/CYT-736-20µg-20µg
产品编号:CYT-736-20µg-20µg
市  场 价:¥2600.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$130.00
品      牌: Prospec
公      司:Prospec-Tany
公司分类:
Prospec/NRG1 A Human/Neuregulin-1/Heregulin Alpha (EGF Domain) Human Recombinant/20µg/CYT-736-20µg-20µg
商品介绍

Cataloguenumber

CYT-736

Synonyms

Neuregulin-1,HeregulinAlpha,NRG1-A,NRG1A.

Introduction

Neuregulin/Heregulinisafamilyofstructurallyrelatedpolypeptidegrowthfactorswhicharestemmedfromalternativelysplicedgenes(NRG1,NRG2,NRG3andNRG4).Thusfar,therearemorethan14solubleandtransmembraneproteinsderivedfromtheNRG1gene.ProteolyticprocessingoftheextracellulardomainofthetransmembraneNRG1isoformsreleasesolublegrowthfactors.Theseisoformscontaintheheregulins(HRGs),glialgrowthfactors(GGFs)andsensoryandmotorneuron-derivedfactor(SMDF).AllthesefactorshavetheIgandEGF-likedomain,andareabletobindtoErbB3andErbB4receptortyrosinkinases.Thisbindingstimulateserb3anderb4heterodimerizationwitherb2,promotingintrinsickinaseactivity,whichresultsintyrosinephosphorylation.NRG1isoformsacttoinducethegrowthanddifferentiationofepithelial,neuronal,glial,andothertypesofcells.

Description

RecombinantHumanNeuregulin-1/HeregulinAlpha(EGFDomain)producedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining65aminoacidsandhavingatotalmolecularmassof7.4kDa.NRG1-Aispurifiedbyproprietarychromatographictechniques.

Source

EscherichiaColi.

PhysicalAppearance

SterileFilteredWhitelyophilized(freeze-dried)powder.

Formulation

Lyophilizedfroma0.2µmfilteredsolutionin20mMPB,pH6.0and150mMNaCl.

Solubility

ItisrecommendedtoreconstitutethelyophilizedNRG1-Ainsterile18M-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.

StABIlity

LyophilizedNRG1-Aalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionNRG1-Ashouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Pleasepreventfreeze-thawcycles.

Purity

Greaterthan97.0%asdeterminedby:(a)AnalysisbyRP-HPLC.(b)AnalysisbySDS-PAGE.

Aminoacidsequence

SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQK.

BIOLOGicalActivity

TheED50wasdeterminedbythedose-dependentstimulationoftheproliferationofhumanMCF-7cellsislessthan40ng/ml,correspondingtoaspecificactivityof>2.5×104units/mg.

SafetyDataSheet

SDS

Usage

Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
品牌介绍

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。

 

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