Catalogue number
PRO-2262
Synonyms
CD69Molecule, CD69 Antigen (P60, Early T-Cell Activation Antigen), Early T-CellActivation Antigen P60, Leukocyte Surface Antigen Leu-23, BL-AC/P26, GP32/28, CLEC2C,MLR-3, AIM, EA1, C-Type Lectin Domain Family 2, Member C, Activation InducerMolecule (AIM/CD69), C-Type Lectin Domain Family 2 Member C, Early LymphocyteActivation Antigen, Activation Inducer Molecule, CD69 Antigen, Early activationantigen CD69.
Introduction
CD69 is a type 2 transmembrane glycoprotein which belongs to the C-typelectin family. CD69 is a very early activation Ag of T lymphocytes. The expressionof CD69 is induced upon activation of T lymphocytes, and CD69 takes part inproliferation. Moreover, CD69 acts to transmit signals in natural killer cellsas well as platelets. CD69 functions in the pathogenesis of allergen induced eosinophilicairway inflammation and responsiveness. Among the diseases which are associatedwith CD69: cd3gamma deficiency and mast cell disease.
Description
CD69 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 147 amino acids (62-199a.a.) andhaving a molecular mass of 17.0kDa.
(Molecular size on SDS-PAGE will appear atapproximately 18-28kDa).
CD69 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,Baculovirus cells.
Physical Appearance
Sterile Filtered clear solution.
Formulation
CD69 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence
ADPSVGQYNC PGQYTFSMPSDSHVSSCSED WVGYQRKCYF ISTVKRSWTS AQNACSEHGA TLAVIDSEKD MNFLKRYAGR EEHWVGLKKE PGHPWKWSNGKEFNNWFNVT GSDKCVFLKN TEVSSMECEK NLYWICNKPY KHHHHHH.
Safety Data Sheet
Usage
Prospec"s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.