Catalogue number
PRO-2255
Synonyms
C1q/MBL/SPAreceptor, C1qR(p), C1qRp, Cell surface antigen AA4, Complement, component 1 qsubcomponent receptor 1, Lymphocyte antigen 68, Ly-68, CD93, Cd93.
Introduction
CD93, is a receptor or else an element of a larger receptor complex forC1q, MBL2-mannose-binding lectin and SPA-pulmonary surfactant protein A. CD93 mediates the enhancement of phagocytosis in monocytes as well asmacrophages upon interaction with soluble defense collagens. CD93 takes part in the intercellular adhesion.Furthermore, CD93 was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells which demonstrated decreasedcell cycle activity, high levels of isotype-switched Ig secretion, as well asmodification of the transcriptional network. CD93 is vital for the maintenanceof plasma cells in bone marrow niches.
Description
CD93 produced in Sf9Insect cells is a single, glycosylated polypeptide chain containing 558 aminoacids (23-572a.a.) and having a molecular mass of 60.1kDa. (Molecular size onSDS-PAGE will appear at approximately 70-100kDa).CD93 is expressed withan 8 amino acid His tag at C-Terminus and purified by proprietarychromatographic techniques. |
Source
Sf9,Insect cells.
Physical Appearance
Sterilefiltered colorless solution.
Formulation
CD93protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity
Greaterthan 95.0% as determined by SDS-PAGE.
Amino acid sequence
ADSQAVVCEG TACYTAHWGK LSAAEAQHRC NENGGNLATV KSEEEARHVQ QALTQLLKTK APLEAKMGKF WIGLQREKGN CTYHDLPMRG FSWVGGGEDT AYSNWYKASK SSCIFKRCVS LILDLSLTPH PSHLPKWHES PCGTPEAPGN SIEGFLCKFN FKGMCRPLAL GGPGRVTYTT PFQATTSSLE AVPFASVANV ACGDEAKSET HYFLCNEKTP GIFHWGSSGP LCVSPKFGCS FNNGGCQQDC FEGGDGSFRC GCRPGFRLLD DLVTCASRNP CSSNPCTGGG MCHSVPLSEN YTCRCPSGYQ LDSSQVHCVD IDECQDSPCA QDCVNTLGSF HCECWVGYQP SGPKEEACED VDECAAANSP CAQGCINTDG SFYCSCKEGY IVSGEDSTQC EDIDECSDAR GNPCDSLCFN TDGSFRCGCP PGWELAPNGV FCSRGTVFSE LPARPPQKED NDDRKESTMP PTEMPSSPSG SKDVSNRAQT TGLFVQSDIP TASVPLEIEI PSEVSDVWFE LGTYLPTTSG HSKPTHEDSV SAHSDTDGQN LEHHHHHH.
Safety Data Sheet
Usage
ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.