PRO-2493
Lymphocytefunction-associatedantigen3isoform1,CD58,ag3,LFA-3,LFA3,SurfaceglycoproteinLFA-3.
CD33isputativeadhesionmoleculeofmyelomonocytic-derivedcellswhichmediatessialic-aciddependentbindingtocells.CD33preferstobindtoalpha-2,6-linkedsialicacid.Thesialicacidrecognitionsiteismaskedbycisinteractionswithsialicacidsonthesamecellsurface.Intheimmuneresponse,CD33performasaninhibitoryreceptoruponligandinducedtyrosinephosphorylationbyrecruitingcytoplasmicphosphatasesthroughtheirSH2domainswhichblocksignaltransductionthroughdephosphorylationofsignalingmolecules.Inaddition,CD33inducesapoptosisinacutemyeloidleukemia.
CD58producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining196aminoacids(29-215a.a.)andhavingamolecularmassof22.5kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).CD58isexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Sf9,Baculoviruscells.
Sterilefilteredcolorlesssolution.
CD58proteinsolution(1mg/ml)containsphosphatebufferedsaline(pH7.4)and10%glycerol.
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Greaterthan95.0%asdeterminedbySDS-PAGE.
SDS
ADPFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRHHHHHH
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。