Ephrin-A4,EPH-relatedreceptortyrosinekinaseligand4,LERK-4,EFNA4,EPLG4,LERK4,EFL4,MGC125826.
EphrinA4isamemberoftheephrin(EPH)family.EphrinsandEPH-relatedreceptorscomprisethelargestsubfamilyofreceptorprotein-tyrosinekinases.Basedupontheirstructuresandsequencerelationships,ephrinsaredividedintotheephrin-A(EFNA)class,whichareattachedtothemembranebyaglycosylphosphatidylinositollinkage,andtheephrin-B(EFNB)class,whicharetransmembraneproteins.ClassAephrinsarelinkedtothemembranebyaGPIlinkageandbindprimarilytoEphAreceptors;ClassBephrinscontainamembrane-spanningregionandbindprimarilytoEphBreceptors.
BothephrinsandEphreceptorsarelargelyexpressedthroughouttheectoderm,mesoderm,andendodermofvertebrateembryos.
EFNAbindstotheEPHA2,EPHA4,EPHA5,EPHA6,andEPHA7receptors.
Twotranscriptvariationswhichencodedifferentisoformswereidentifiedthroughsequenceanalysis.DuringdevelopmenttheEphreceptorandtheirmembrane-attachedligands,ephrins,showdiverseexpressionpatterns.
TheephrinsandEPH-relatedreceptorsmediatedevelopmentalevents,principallyinthenervoussystemandinerythropoiesis.ThecriticalrolesofEphandephrinsduringdevelopmentimplyinvolvementofthesegenesincongenitaldisordersaffectingthenervoussystemandothertissues.
EphrinsandEphreceptorsareposs
IBLyinvolvedincarcinogenesis.
EphrinA4HumanRecombinantfulllengthproteinexpressedinE.coli,showsa46kDaSDS-PAGE(IncludingGSTtag).TheEphrinA4ispurifiedbyproprietarychromatographictechniques.
EscherichiaColi.
SterileFilteredclearsolution.
EphrinA4proteinin50mMTris-Acetate,pH7.5,1mMEDTAand20%Glycerol.
Storevialat-20°Cto-80°C.Whenstoredattherecommendedtemperature,thisproteinisstablefor12months.
Pleasepreventfreeze-thawcycles.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.