Cataloguenumber
ENZ-517
Synonyms
EC3.5.3.1,Arginase1,TypeIArginase,Liver-TypeArginase.
Introduction
ARG1catalyzesthehydrolysisofargininetoornithineandurea.2isoformsofmammalianarginaseexistwhichvaryintheirtissuedistribution,subcellularlocalization,immunologiccrossreactivityandphysiologicrole.ARG1isacytosolicenzymeandexpressedwidelyintheliveraspartoftheureacycle.InheriteddeficiencyofthisARG1causesargininemia,whichisanautosomalrecessivedisordercharacterizedbyhyperammonemia.
Description
ARG1HumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining330aminoacids(1-322a.a.)andhavingamolecularmassof35.8kDa.ARG1proteinisfusedtoan8aminoacidHistagatC-terminusandispurifiedbystandardchromatography.
Source
EscherichiaColi.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
ARG1Humanproteinsolution(0.5mg/ml)containing20mMTris-HClpH-8,2mMDTT,0.1MNaCl&20%glycerol.
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan85%asdeterminedbySDS-PAGE.
Aminoacidsequence
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPF
ADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
LEHHHHHH.
Usage
Prospec"sproductsarefurnishedfor LABORATORYRESEARCH USE ONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.