Cataloguenumber
ANT-461
Synonyms
Alpha-synuclein,Non-AbetacomponentofADamyloid,Non-A4componentofamyloidprecursor,NACP,PD1,PARK1,PARK4,MGC110988,a-Synuclein,SNCA.
Type
MouseAntiHumanMonoclonal.
Introduction
a-Synuclein(aminoacids1-140),anacidicneuronalproteinof140aminoacids,isextremelyheat-resistantandisnativelyunfoldedwithanextendedstructureprimarilycomposedofrandomcoils.a-synucleinhasbeensuggestedtobeimplicatedinthepathogenesisofParkinson’sdiseaseandrelatedneurodegenerativedisorders,andmorerecently,tobeanimportantregulatorycomponentofvesiculartransportinneuronalcells.Moreover,recentstudieshaveshownthata-synucleinhaschaperoneactivityandthatthisactivityislostuponremovingitsC-terminalacidictail(aminoacids96-140).
Clone
PAT1E10A.
Immunogen
Anti-humanSNCAmAb,clonePAT1E10A,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanSNCAprotein1-140aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG1heavychainandKappalightchain.
PurificationMethod
SNCAantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
PhysicalAppearance
SterileFilteredcolorlesssolution.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.01%SodiumAzide.
StorageProcedures
Forperiodsupto1monthstoreat4°C,forlongerperiodsoftime,storeat-20°C.
Preventfreezethawcycles.
Applications
Theantibodyhasbeentestedby
ELISAandWesternblotanalysistoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.Recommendedstartingdilutionis1:500.
SafetyDataSheet
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.