LSM2homologU6smallnuclearRNAassociated(S.cerevisiae),SmallnuclearribonuclearproteinDhomolog,chromosome6openre
ADIngframe28,snRNPcoreSm-likeproteinSm-x5,C6orf28,YBL026W,ProteinG7b,snRNP.
LSM2isamemberofthesnRNPSmproteinsfamily.Sm-likeproteinsarebrandedinseveralorganismsbasedonsequencehomologywiththeSmproteinfamily.Sm-likeproteinsholdtheSmsequencemotifthatismadeupof2regionsseparatedbyalinkerofvariablelengthwhichfoldsasaloop.TheSm-likeproteinsarebelievedtocreateasteadyheteromerpresentintri-snRNPparticles,whicharevitalforpre-mRNAsplicing.LSM2bindsspecificallytothe3"-terminalU-tractofU6snRNAnadtakespartinpre-mRNAsplicing.
LSM2HumanRecombinantproducedinE.coliisasinglepolypeptidechaincontaining119aminoacids(1-95)andhavingamolecularmassof13.4kDa.LSM2isfusedtoa24aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
E.coli.
SterileFilteredcolorlesssolution.
TheLSM2solution(0.5mg/1ml)contains20mMTris-HClbuffer(pH8.0),200mMNacl,5mMDTTand40%glycerol.
Greaterthan90%asdeterminedbySDS-PAGE.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.