Papillomavirus,HPV,PapillomaVirus.
Humanpapillomaviruses(HPVs)areagroupfamilywithmorethan150relatedviruses.HP6and11consideredaslow-riskHPVscanbesexuallytransmitted,causingwartstoemergeonoraroundthegenitalsoranus,knownascondylomataacuminate.HPV-6major/largecapsidantigenisusedinclinicaldiagnosistotestthespecificantibodytothisvirusinducedbythevirusinfection,thepositivereactionofthisantibodyisdeemedasa
Markerforpresentandpastinfection.Fur
Thermore,HPV-6largecapsidisusedasapotentialcandidateforvaccinedevelopment.
RecombinantHPV6antigenisa55.6kDaproteincoveringthefulllengthofHPV6majorcapsid,itsN-terminusisfusedwithaGSTtag,havingatotalMwof81.6kDa.TheHPV6wasPurifiedbyproprietarychromatographictechnique.
E.Coli.
Sterilefilteredclearliquidformulation.
RecombinantHPV-6althoughstableat4°Cfor1week,shouldbestoredbelow-18°C.Pleasepreventfreezethawcycles.
Proteinis>90%pureasdeterminedby10%PAGE(coomassiestaining).
VDVPPPNPVSKVVATDAYVTRTNIFYHASSSRLLAVGHPYFSIKRANKTVVPKVSGYQYRVFKVVLPDPNKFALPDSSLFDPTTQRLVWACTGLEVGRGQPLGVGVSGHPFLNKYDDVENSGSGGNPGQDNRVNVGMDYKQTQLCMVGCAPPLGEHWGKGKQCTNTPVQAGDCPPLELITSVIQDGDMVDTGFGAMNFADLQTNKSDVPIDICGTTCKYPDYLQMAADPYGDRLFFFLRKEQMFARHFFNRAGEVGEPVPDTLIIKGSGNRTSVGSSIYVNTPSGSLVSSEAQLFNKPYWLQKAQGHNNGICWGNQLFVTVVDTTRSTNMTLCASVTTSSTYTNSDYKEYMRHVEEYDLQFIFQLCSITLSAEVMAYIHTMNPSVLEDWNFGLSPPPNGTLEDTYRYVQSQAITCQKPTPEKEKPDPYKNLSFWEVNLKEKFSSELDQYPLGRKFLLQSGYRGRSSIRTGVKRPAVSKASAAPKRKRAK.
Eachlaboratoryshoulddetermineanoptimumworkingtiterforuseinitsparticularapplication.
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.