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℡ 4000-520-616
℡ 4000-520-616
Prospec/FLT4 Human/Vascular Endothelial Growth Factor Receptor-3 Human Recombinant/1mg/PKA-244-1mg-1mg
产品编号:PKA-244-1mg-1mg
市  场 价:¥104000.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$5200.00
品      牌: Prospec
公      司:Prospec-Tany
公司分类:
Prospec/FLT4 Human/Vascular Endothelial Growth Factor Receptor-3 Human Recombinant/1mg/PKA-244-1mg-1mg
商品介绍

Cataloguenumber

PKA-244

Synonyms

Tyrosine-proteinkinasereceptorFLT4,PCL,FLT41,FMS-LIKETYROSINEKINASE4,VEGFR-3,VEGFR3.

Introduction

AllthreeVEGFreceptorsbelongtotheclassIIIsubfamilyofreceptortyrosinekinases(RTKs)characterisedbythesevenimmunoglobulin-likeloopsintheextracellulardomain.TheexpressionofVEGFR-1to-3isalmostexclusivelyrestrictedtohematopoieticprecursorcells,vascularandlymphaticendothelialcellsandtothemonocyte/macrophagelineage.Theyplaykeyrolesinvasculogenesis,hematopoiesis,angiogenesisandlymphangiogenesis.TheFLT-4CDNAencodesa1298aminoacid(aa)residueprecursorproteinwitha23aaresiduesignalpeptide.MatureVEGFR-3/FLT-4iscomposedofa751aaresidueextracellulardomain,a22aatransmembranedomainanda482aaresiduecytoplasmicdomain.BothVEGFfamilymembersVEGF-CandVEGF-DhavebeenshowntobindandactivateVEGFR-3/FLT-4.TheFlt-4geneiswidelyexpressedintheearlyembryobutbecomesrestrictedtothelymphaticendothelialalatterstagesofdevelopment.Itisimportantforlymphangiogenesis.

Description

SolubleFLT4HumanRecombinantfusedwithacarboxy-terminal6Xhistidine-tagproducedinbaculovirusisamonomeric,glycosylated,polypeptidecontainingtheextracellularpart,25-774aminoacidsandhavingatotalmolecularmassof120kDa.Thesolublereceptorproteincontainsonlythefirst7extracellulardomains,whichcontainalltheinformationnecessaryforligandbinding.TheFLT4ispurifiedbyproprietarychromatographictechniques.

Source

InsectCells.

PhysicalAppearance

SterileFilteredWhitelyophilized(freeze-dried)powder.

Formulation

FLT4waslyophilizedfromaconcentrated(1mg/ml)sterilesolutioncontaining1xPBS.

Solubility

ItisrecommendedtoreconstitutethelyophilizedFLT4insterilewaternotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.

StABIlity

LyophilizedFLT4althoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionFLT4shouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.

Purity

Greaterthan90.0%asdeterminedbySDS-PAGE.

BIOLOGicalActivity

MeasuredbyitsabilitytobindrecombinantratVEGF-Cinafunctionalsolidphasebindingassay.ImmobilisedrecombinanthumanVEGFR-3/FLT-4at5µg/mlcanbindrecombinantratVEGF-Cinalinearrangeof8-500ng/ml.

SafetyDataSheet

SDS

Usage

Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
品牌介绍

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。

 

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