Prospec/4 1BBL Human/4-1BB Ligand Human Recombinant/20µg/CYT-149-20µg,Prospec,,Prospec,prospecbio,ProSpec-Tany,进口Prospec现货 ProSpec病毒抗原,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Prospec/4 1BBL Human/4-1BB Ligand Human Recombinant/20µg/CYT-149-20µg

产品编号：CYT-149-20µg

市场价：¥2600.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$130.00

品牌： Prospec

公司：Prospec-Tany

公司分类：

商品介绍

Cataloguenumber

CYT-149

Synonyms

CD137L,CD137-L,4-1BBL,4-1BBLigand,TNFSF9,TumorNecrosisFactor(ligand)SuperfamilyMember9.

Introduction

4-1BBLisatransmembranecytokinethatispartofthetumornecrosisfactor(TNF)ligandfamily.4-1BBLisabidirectionalsignaltransducerthatperformsasaligandforTNFRSF9,whichisacostimulatoryreceptormoleculeinTlymphocytes.TNFSF9anditsTNFRSF9takepartintheantigenpresentationdevelopmentandinthegenerationofcytotoxicTcells.4-1BBRisabsentfromrestingTlymphocytesbutrapidlyexpresseduponantigenicstimulation.TNFSF9reactivatesanergicTlymphocytesaswellaspromotingTlymphocyteproliferation.4-1BBLigandisneededfortheoptimalCD8responsesinCD8Tcells.4-1BBLisexpressedincarcinomacelllines,andisthoughttobeinvolvedinTcell-tumorcellinteraction.4-1BBLisexpressedbyactivatedBcells,macrophages,dendriticcells,activatedTcells,neuronsandastrocytes.Theinteractionof4-1BBwithTNFRSF9stronglyregulatesimmunityandhasbeenproposedtopreferentiallycontrolTcellresponsesbasedonstudiesinvariousmurin.

Description

41BBLHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining184aminoacidsandhavingamolecularmassof19.5kDa.The41BBLispurifiedbyproprietarychromatographictechniques.

Source

EscherichiaColi.

PhysicalAppearance

SterileFilteredWhitelyophilized(freeze-dried)powder.

Formulation

Lyophilizedfroma0.2µmfilteredconcentratedsolutioninPBS,pH7.4.

Solubility

Itisrecommendedtoreconstitutethelyophilized41BBLinsterile18M-cmH₂Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.

StABIlity

Lyophilized41BBLalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.Uponreconstitution41BBLshouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Pleasepreventfreeze-thawcycles.

Purity

Greaterthan95.0%asdeterminedbySDS-PAGE.

Aminoacidsequence

REGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE

BIOLOGicalActivity

Fullybiologicallyactivewhencomparedtostandard.Determinedbythedose-dependentstimulationofIL-8productionbyhumanPBMC.TheED50forthiseffectis5-10ng/mlcorrespondingtoaSpecificActivityof100,000-200,000IU/mg.

SafetyDataSheet

SDS

Usage

Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.

品牌介绍

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。